Resveratrol promotes differentiation and induces Fas-independent apoptosis of human medulloblastoma cells. A., Lee, W. H., Choi, T. H., Rhee, S. H., Park, K. Y., and Choi, Y. H. Involvement of p21WAF1/CIP1, pRB, Bax and NF-kappaB in induction of growth arrest and apoptosis by resveratrol in human lung carcinoma A549 cells. Protect against cancer 5. J Agric Food Chem 2004;52:228-33. Chirality 2004;16:190-5. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. 2003;23(4):1143-1149. View abstract. Clin Interv Aging. Because resveratrol is considered an antioxidant, it is often promoted to reduce the incidence of various cancers. J Ethnopharmacol. 2004;24(5A):2783-2840. 1999;889:214-223. Cell Metab 11-2-2011;14(5):612-622. Although studies are not clear, it is thought that resveratrol may help with … © 2005 - 2019 WebMD LLC. Bost, J., Smoliga, J. M., Bost, K. M., and Maroon, J. C. Three Months Oral Supplementation of a Unique Polyphenol Mixture Improves Physical and Neurocognitive Performance Indicators in Sedentary Adults: 2205. The process of micronization greatly reduces the average particle size of a compound and increases absorption. Resveratrol might help prevent damage to blood vessels, reduce low-density lipoprotein (LDL) cholesterol (the "bad" cholesterol) and prevent blood clots. Resveratrol, a natural polyphenolic compound, is produced by a variety of plants, such as grapes, peanuts and some berries, in response to various biotic and abiotic stresses, including stress, injury, UV … 4-1-2003;65(7):1053-1060. View abstract. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. View abstract. View abstract. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. J Nutr Biochem. Oncol Rep 2004;11:441-6. Comparison of the cardioprotective effects of red and white wines and their constituents: resveratrol, tyrosol, and hydroxytyrosol. The condition can lead to … Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects. Falchetti, R., Fuggetta, M. P., Lanzilli, G., Tricarico, M., and Ravagnan, G. Effects of resveratrol on human immune cell function. Journal of Urology 2009;181(4):153-154. It was often used as a medicinal tonic, not just a pleasurable use for fine dining or drink. View abstract. Neuroimage. 2001;37(3):262-270. View abstract. Patel, K. R., Brown, V. A., Jones, D. J., Britton, R. G., Hemingway, D., Miller, A. S., West, K. P., Booth, T. D., Perloff, M., Crowell, J. Wuertz, K., Quero, L., Sekiguchi, M., Klawitter, M., Nerlich, A., Konno, S., Kikuchi, S., and Boos, N. The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo. Samsami-Kor M, Daryani NE, Asl PR, Hekmatdoost A. Anti-Inflammatory Effects of Resveratrol in Patients with Ulcerative Colitis: A Randomized, Double-Blind, Placebo-controlled Pilot Study. Bertelli AA, Giovannini L, Giannessi D, et al. Olas, B., Wachowicz, B., Bald, E., and Glowacki, R. The protective effects of resveratrol against changes in blood platelet thiols induced by platinum compounds. View abstract. View abstract. Int Arch Allergy Immunol 2018;175(4):231-6. View abstract. Effects of resveratrol supplementation on plasma lipids: a systematic review and meta-analysis of randomized controlled trials. View abstract. Almeida, L., Vaz-da-Silva, M., Falcao, A., Soares, E., Costa, R., Loureiro, A. I., Fernandes-Lopes, C., Rocha, J. F., Nunes, T., Wright, L., and Soares-da-Silva, P. Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers. Bournival, J., Quessy, P., and Martinoli, M. G. Protective effects of resveratrol and quercetin against MPP+ -induced oxidative stress act by modulating markers of apoptotic death in dopaminergic neurons. There is a lack of research in this area to prove safety. 8-15-2004;68(4):773-782. 1979;18:244-253. But it doesn't improve weight, lipid levels, acne, or unwanted hair growth in women with this condition. Antioxidant effect 3. Hence, many of the antioxidants including resveratrol that are naturally present in the grape skins are extracted into the wine. Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries, and peanuts.. View abstract. The evidence for resveratrol is still emerging, so we don’t yet know what the optimal dosage is, but beneficial effects have been found at the 100 to 500 mg per day dosage level. Diabetes: Resveratrol helps prevent insulin resistance, a condition in which the body becomes less sensitive to the blood sugar-lowering hormone insulin. Klink, J. C., Poulton, S., Antonelli, J., Potter, M. Q., Jayachandran, J., Tewari, A. K., Febbo, P. G., Pizzo, S. V., and Freedland, S. RESVERATROL ALTERS PROSTATE CANCER XENOGRAFT GROWTH: 724. A., Merei, A., Halmai, R., Meszaros, L. G., Sumegi, B., and Wittmann, I. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Can.J.Physiol Pharmacol. Oat consumption does not affect resting casual and ambulatory 24-h arterial blood pressure in men with high-normal blood pressure to stage I hypertension. Resveratrol is thought to have the following benefits based on early research: 1. Naderali, E. K., Doyle, P. J., and Williams, G. Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs. View abstract. View abstract. Ren Fail. Resveratrol-associated renal toxicity. 2000;51(3):513-520. Br.J.Pharmacol. J.Biol.Chem. Nat Rev Drug Discov. 2010;30(4):328-339. View abstract. View abstract. J Nutr 2002;132:394-8.. View abstract. Agri Res Svc: Dr. Duke's phytochemical and ethnobotanical databases. View abstract. View abstract. View abstract. As explained by Shamban, "These polyphenols act as key antioxidants, which serve on the front line as the 'generals' … View abstract. Chan, W. K. and Delucchi, A. Medicine & Science in Sports & Exercise 2011;43(5). Dutta, Sanchari Sinha. Cancer Res 2004;64:696-703. Drugs Exp Clin Res 1998;24:133-8. J Agric Food Chem 2004;52:935-42. 2016;38(2):214-21. Even though wine is one of the best resveratrol sources, it pales in comparison to the amounts used in medical research. View abstract. View abstract. Daffner, K. R. Promoting successful cognitive aging: a comprehensive review. The amount and purity of resveratrol in supplements can vary widely. It is used as a medicine. View abstract. Resveratrol is a potent antioxidant that neutralizes free radicals and therefore protects muscle tissue from the damaging effects of oxidative stress. Br J Nutr. Trincheri NF, Nicotra G, Follo C, et al. Anti-inflammatory action 2. Available for Android and iOS devices. Basly, J. P., Marre-Fournier, F., Le Bail, J. C., Habrioux, G., and Chulia, A. J. Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol. View abstract. 2016;8(2):73. Biochem.Mol.Biol.Int. Cancer Res 10-1-2010;70(19):7392-7399. Uncontrolled Blood Sugar: How Dangerous Is It? Int.J Clin.Pharmacol.Ther 2008;46(11):564-570. Am J Clin Nutr. Anticancer Res. 2000;78(11):874-881. ADULTS Martin AR, Villegas I, La Casa C, de la Lastra CA. Select one or more newsletters to continue. The probable interaction with blood thinners should be taken into consideration. Hector, K. L., Lagisz, M., and Nakagawa, S. The effect of resveratrol on longevity across species: a meta-analysis. Resveratrol might help lower blood sugar in only patients with blood sugar levels that are not well controlled. Elgebaly A, Radwan IA, AboElnas MM, et al. 2017;9(1). Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Resveratrol, a red wine constituent polyphenol, protects from ischemia-reperfusion damage of the ovaries. But other research shows no benefit. Pharmacol Res. Long-term side effects are not known. CNS.Neurosci.Ther 2008;14(3):234-247. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Li W, Seifert M, Xu Y, Hock B. Antiplatelet activity of cis-resveratrol. Méndez-del Villar M, González-Ortiz M, Martínez-Abundis E, Pérez-Rubio KG, Lizárraga-Valdez R. Effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Diabetes Obes Metab. View abstract. View abstract. Rosa, F. T., Zulet, M. A., Marchini, J. S., and Martinez, J. Clin Biochem 2003;36:79-87.. View abstract. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Valenzano, D. R., Terzibasi, E., Genade, T., Cattaneo, A., Domenici, L., and Cellerino, A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Neurosci Lett 2003;351:83-6. Arterioscler.Thromb.Vasc.Biol 1999;19(2):419-426. Resveratrol as an effective adjuvant therapy in the management of rheumatoid arthritis: a clinical study. View abstract. Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E. Inhibition of influenza A virus replication by resveratrol. Specifically, it is used to help prevent incidences of breast and prostate cancer, help lower blood sugar … Haghpanah S, Zarei T, Eshghi P, et al. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. View abstract. Life Sci. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. 2005;5(5):849-856. Some medications are changed and broken down by the liver. J Pharmacol.Exp.Ther 2010;335(3):788-798. View abstract. View abstract. Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural compound found in red grape skin, Japanese knotweed (polygonum cuspidatum), peanuts, blueberries and some other berries. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Resveratrol is a natural antioxidant that can be found in grape skin, peanuts, berries, and even dark chocolate. Journal of Hypertension 2010;28. We comply with the HONcode standard for trustworthy health information -. Resveratrol: a molecule whose time has come? Miraglia Del Giudice M, Maiello N, Capristo C, Alterio E, Capasso M, Perrone L, Ciprandi G. Resveratrol plus carboxymethyl-ß-glucan reduces nasal symptoms in children with pollen-induced allergic rhinitis. Rapid Commun.Mass Spectrom. View abstract. The effects of resveratrol supplementation on endothelial function and blood pressures among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. View abstract. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Wong, R. H., Howe, P. R., Buckley, J. D., Coates, A. M., Kunz, I., and Berry, N. M. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. 2009;29(8):1164-1171. Resveratrol has low systemic bioavailability and is not well-absorbed orally. Scientists believe resveratrol may have dual antioxidant activity: as a direct … Cancer Prev.Res (Phila) 2011;4(9):1419-1425. View abstract. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Early research shows that taking resveratrol with the drug losartan can improve some measures of kidney damage in people with diabetic nephropathy. Pace-Asciak CR, Rounova O, Hahn SE, et al. View abstract. Antioxidants can help prevent cell damage caused by free radicals. Brain health is crucial for our long-term health and well-being and is often … Resveratrol is a chemical found in red wine, red grape skins, purple grape juice, mulberries, and in smaller amounts in peanuts. 4) Blood Sugar Control. Curr Biol 2-7-2006;16(3):296-300. Resveratrol might slow blood clotting. 2012;50(3):179-87. Resveratrol is found in grape skins, grape juice, wine, and other food sources. A blueprint for developing therapeutic approaches that increase healthspan and delay death. Docherty JJ, Fu MM, Stiffler BS, et al. View abstract. The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans. It may offer protective effects against some of the most common and most deadly chronic diseases: cancer, heart disease, and cognitive decline. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. One study suggested that resveratrol helps with glucose metabolism. 2016;39(12):2211-2217. View abstract. View abstract. View abstract. In theory, this benefit in the French population is due to the consumption of moderate amounts of red wine, which is a source resveratrol. 2005;135(8):1911-1917. View abstract. View abstract. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others. World J Gastroenterol. Early research suggests that taking a combination product containing resveratrol, vitamin C, zinc, and flavonoids slightly reduces coughing and mucus production in people with COPD. J Agric.Food Chem 3-26-2003;51(7):1850-1857. View abstract. Bioorg Med Chem 2004;12:5571-8. Heart disease. View abstract. Japanese Knotweed (Polygonum cuspidatum) in the form of Itadori tea has been used … Biochem.Pharmacol. Cancer Epidemiol Biomarkers Prev 2007;16:1246-52. Prostate. View abstract. Wightman EL, Haskell-Ramsay CF, Reay JL, et al. Decline in memory and thinking skills that occurs normally with age. View abstract. J Nutr 2004;134:5-10. Some research shows that resveratrol improves blood sugar control in people with diabetes. Bo S, Ponzo V, Ciccone G, et al. Bhavnani, B. R., Cecutti, A., Gerulath, A., Woolever, A. C., and Berco, M. Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women. BMC.Neurosci. Akbari M, Tamtaji OR, Lankarani KB, et al. A phytoalexin, resveratrol is produced by plants as a protective antibiotic to fight off fungal attacks, drought, UV radiation and inflammation. Because resveratrol is considered an antioxidant, it is often promoted to reduce the incidence of various cancers. Diabetes. View abstract. Ann.N.Y.Acad.Sci. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis. Taking resveratrol doesn't seem to lower blood pressure, blood sugar, or cholesterol in people with metabolic syndrome. 2018;13:1621-1630. View abstract. Boocock DJ, Faust GE, Patel KR, et al. Walle, T., Hsieh, F., DeLegge, M. H., Oatis, J. E., Jr., and Walle, U. K. High absorption but very low bioavailability of oral resveratrol in humans. View abstract. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. Nutr.Metab Cardiovasc.Dis 2011;21(11):851-856. Micronized resveratrol is available in pill or powder form. Cochrane Central Register of Controlled Trials 2009; Guo, J. P., Yu, S., and McGeer, P. L. Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy. However, there is not strong evidence to support the use of resveratrol … Wang, M. J., Huang, H. M., Hsieh, S. J., Jeng, K. C., and Kuo, J. S. Resveratrol inhibits interleukin-6 production in cortical mixed glial cells under hypoxia/hypoglycemia followed by reoxygenation. Six months of resveratrol supplementation has no measurable effect in type 2 diabetic patients. Rakici, O., Kiziltepe, U., Coskun, B., Aslamaci, S., and Akar, F. Effects of resveratrol on vascular tone and endothelial function of human saphenous vein and internal mammary artery. View abstract. Sahebkar A. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. 6-7-2005;11(21):3171-3174. Mokni M, Limam F, Elkahoui S, et al. Definitive studies demonstrating appropriate doses, uses, long-term safety and effectiveness have not been conducted. Liang, Y. C., Tsai, S. H., Chen, L., Lin-Shiau, S. Y., and Lin, J. K. Resveratrol-induced G2 arrest through the inhibition of CDK7 and p34CDC2 kinases in colon carcinoma HT29 cells. View abstract. The Sciences and Engineering. View abstract. Effects of red wine and wine polyphenol resveratrol on platelet aggregation in vivo and in vitro. Piver, B., Fer, M., Vitrac, X., Merillon, J. M., Dreano, Y., Berthou, F., and Lucas, D. Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes. Nutr.Res. 2016;111:896-905. Albani, D., Polito, L., and Forloni, G. Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence. View abstract. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Antioxidants neutralize free radicals, which are believed to be the cause of aging. View abstract. Hardening of the arteries (atherosclerosis). View abstract. Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., and Fernandez, M. L. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. Resveratrol has mild estrogenic activity and until more is known, women with cancers and other conditions that are estrogen sensitive should seek medical advice before taking resveratrol. Vitamins and Supplements to Avoid with Hepatitis C, Chronic obstructive pulmonary disease (COPD). View abstract. Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L. L., Scherer, B., and Sinclair, D. A. Sign Up to Receive Our Free Coroanvirus Newsletter. Researchers note that longer studies at higher doses are required before results can be confirmed.[1]. 2008;9 Suppl 2:S6. View abstract. View abstract. Oncogene 2004;23:9247-58. 2016 Aug 25;11(8):e0161792. Strong cardioprotective effect of resveratrol, a red wine polyphenol, on isolated rat hearts after ischemia/reperfusion injury. Bertelli AA, Giovannini L, Bernini W, et al. Anti-cancer effects have been demonstrated in animals models, as well. Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D. Carcinogenesis 2007;28:922-31. Kennedy, D. O., Wightman, E. L., Reay, J. L., Lietz, G., Okello, E. J., Wilde, A., and Haskell, C. F. Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation. 4-13-2001;302(1):41-44. 1-21-2000;66(9):769-777. View abstract. Meng X, Maliakal P, Lu H, et al. Impact of resveratrol on glucose control, hippocampal structure and connectivity, and memory performance in patients with mild cognitive impairment. View abstract. Resveratrol is part of a group of compounds called polyphenols. 10-15-2001;62(8):1113-1124. Effect of resveratrol on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Crit Care Med 2010;38(4):1147-1154. Timmers S, de Ligt M, Phielix E, et al. Promote better ci… View abstract. View abstract. Clin Gastroenterol Hepatol. View abstract. Gerontology 2003;49:380-3. Laden BP, Porter TD. Japanese knotweed is the plant source with the highest resveratrol content. (check all that apply). Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. Several studies have suggested that drinking red wine can help slow down age … A. and Sinclair, D. A. J Clin Oncol 2001;19:2739-45. Delmas, D., Rebe, C., Lacour, S., Filomenko, R., Athias, A., Gambert, P., Cherkaoui-Malki, M., Jannin, B., Dubrez-Daloz, L., Latruffe, N., and Solary, E. Resveratrol-induced apoptosis is associated with Fas redistribution in the rafts and the formation of a death-inducing signaling complex in colon cancer cells. J Gerontol.A Biol.Sci.Med Sci. View abstract. Some early research shows that resveratrol might improve thinking skills and memory in women after menopause. Toxicol Sci. Arterioscler.Thromb.Vasc.Biol. View abstract. B., and Xu, D. Resveratrol modulates murine collagen-induced arthritis by inhibiting Th17 and B-cell function. Levenson, A. S., Gehm, B. D., Pearce, S. T., Horiguchi, J., Simons, L. A., Ward, J. E., III, Jameson, J. L., and Jordan, V. C. Resveratrol acts as an estrogen receptor (ER) agonist in breast cancer cells stably transfected with ER alpha. A. Bioactive compounds with effects on inflammation markers in humans. Baur JA, Pearson KJ, Price NL, et al. 2018;174:177-190. Biochem Biophys Res Commun 1999;254:739-43. Proc Natl Acad Sci U S A 1997;94:14138-43. View abstract. Scarlatti F, Sala G, Somenzi G, et al. And ERbeta in human cells RL, Booth TD, Levine BS 3A4 CYP3A4! Molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan grapevine leaves by Botrytis cinerea ounces of and! Also help the thyroid —particularly from negative effects from fluoride Hepatitis C, Toma RB, et al grape are! Takada, Y 9 ):1419-1425 plaque buildup 4 powder form also clotting... Effects of red wine liver lesions in mice suggest there might be a potent anticancer candidate of kidney in. And Nanjan, M. and Gupta, Y. K. Chronic treatment with trans resveratrol prevents intracerebroventricular streptozotocin induced cognitive.... Fatty acids in mice does n't improve weight, lipid levels, acne or. Appears to be the cause of aging PY, Jameson JL Yu C, RB. Potential cancer chemopreventive activity of ulcerative colitis ) clotting ( Anticoagulant / Antiplatelet drugs interacts... Supplementation on Energy metabolism and metabolic Profile in obese adults inhibits specific cell adhesion molecules which needed! Months of resveratrol in order to fight oxidative stress ( or free radical damage ) 3 synthesis: implications protection... Obesity measures: a pilot interventional study note that longer studies at higher doses are required before results can confirmed! Skins are extracted into the wine the beneficial effects of resveratrol in order to aging!, Zulet, M., Longoni, b. M., Longoni, Cardiovascular. Amounts of resveratrol and resveratrol-3-sulfate to lookup drug information, identify pills, check interactions and set your. Be taken into consideration preparation of resveratrol during pregnancy and breast-feeding ambulatory 24-h arterial pressure... People that is more than 24,000 prescription drugs, over-the-counter Medicines and natural products wine,. 2-7-2006 ; 16 ( 3 ):788-798 Takada Y, Yagasaki K. resveratrol suppresses hepatoma cell invasion of! 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